New Spiro[cycloalkane-pyridazinone] Derivatives with Favorable Fsp3 Character
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چکیده
منابع مشابه
Synthesis and biological evaluation of some new pyridazinone derivatives.
A series of pyridazinone derivatives (19-34) were synthesized with an aim to synthesize safer anti-inflammatory agents. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation (LPO) actions. The percentage inhibition in edema at different time intervals indicated that compounds 20, 26, 28 and 34 exhibited good anti-inflammatory potential, comparab...
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In the recent years there has been an increased interest in the pyridazinone ring system. Many investigations indicated that the presence of at least one aryl group, one or two electron donor atoms and/or an NH group in a special spatial arrangement is necessary for anticonvulsant activity. Many investigations indicated that the presence of at least one aryl group, one or two electron donor ato...
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New 3(2H)-pyridazinone derivatives containing a N'-benzyliden-acetohydrazide moiety at position 2 were synthesized. The structures of these newly synthesized compounds were confirmed by IR, 1H NMR, and MS data. These compounds were tested for their antibacterial, antifungal, antimycobacterial, and cytotoxic activities. The compounds 2-[4-(4-chlorophenyl)-6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-...
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ABSTRACT There has been an increasing interest in the chemistry of pyridazinone derivatives because of their biological significance. Pyridazinones have been reported to possess variety of biological activities like antidiabetic, anticancer, anti-AIDS, cardiovascular, antiinflammatory, anticonvulsant and cerebroprotective, analgesics, antidepressant, anticonvulsant, antiasthmatic, anti-HIV1, an...
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Scoliosis, kyphosis, and bone fracture are health problems, especially of the elderly throughout the world. The vertebra protects the spinal cord. Any impairment to the vertebra can lead to pain and nervousness. Ni-Ti alloy (Nitinol) helps to resolve the problem by fulfilling such requirements as for strength, durability, resistance to wear, and shockwave damping which is due to the shape memor...
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ژورنال
عنوان ژورنال: Chemistry
سال: 2020
ISSN: 2624-8549
DOI: 10.3390/chemistry2040055